CARYOPHYLLENE- EXPLORING THE CANNABIS TERPENE CAROPHYLLENE

Known for its spicy, pepperiness, this terpene is found in many edible plants of the world. Black pepper, cloves, cinnamon, oregano, basil, hops, and even rosemary has Caryophyllene.

CANNABINOIDS AND TERPENES

Cannabis plants are loaded with cannabinoids, many of which are widely known by people who don’t even use cannabis.

THC-9, for example, is the cannabinoid most associated with getting ‘stoned’ because it has the psychoactive effect on the mind that so many have come to associate with marijuana.

There are many more cannabinoids that also have important roles to play, such as CBD, otherwise known as cannabidiol.

Terpenes and terpenoids are another part of the puzzle that makes cannabis such a mysterious plant that seems to have been given to us as a gift, for its many uses.

Terpenes give plants their scent and their flavor. Caryophyllene is one of the terpenes found in cannabis. Known for its spicy, pepperiness, this terpene is found in many edible plants of the world. Black pepper, cloves, cinnamon, oregano, basil, hops, and even rosemary has Caryophyllene.

THE ENTOURAGE EFFECT

Scientists believe that terpenes and cannabinoids work especially well when paired with other terpenes and cannabinoids. This is specifically known as the Entourage Effect (E.E.). 

While research into the details of the entourage effect in reference to specific cannabinoids is still in its infancy, Scientists are beginning to separate the cannabinoids and terpenes and single them out with molecular isolation technology. Future research will see scientists test cannabinoids and terpenes in varying combinations, and at different percentages, to see which work best together and what amounts are optimal.

CARYOPHYLLENE IN THE BODY

Caryophyllene likes to stimulate the CB2 receptors of the Endocannabinoid System (ECS) which gives it the potential to be an anti-inflammatory and analgesic. It also can help to reduce cravings, particularly for alcohol. The antioxidant properties help to fight cancer and reduce cancer cell production and it is also a powerful antidepressant and anxiety reducer.

Certain strains of marijuana have been specifically cultivated to produce higher concentrations of this terpene because of its potential benefit to those with any of the above afflictions. It also produces a very flavorful blend of marijuana for those who smoke. Also, because of the way it interacts with the CB2 receptors, Caryophyllene works very much like a cannabinoid does, without the high that you get from THC.

In regards to scientific research, in 2014 a research study was published in “Neuropsychopharmacology” journal which examined the effects of Caryophyllene for pain in mice. It specifically made note of the ability of this terpene to interact with CB2 receptors (this receptor plays an important role in regulation of pain, both neuropathic and inflammatory). This research concluded that oral doses of Caryophyllene reduced the pain responses for inflammation and also for spinal inflammation in the neural network. As a result, it is believed that Caryophyllene could have enormous impacts on the treatment of pain going forward.

CARYOPHYLLENE AND CB2 RECEPTORS

This terpene likes to stimulate the CB2 receptors of the Endocannabinoid System (ECS) which gives it the potential to be an anti-inflammatory and analgesic.

WHAT CONDITIONS CAN CARYOPHYLLENE TREAT?

While research is still in it’s infancy, it is believed that the cannabis terpene Caryophyllene is likely to help treat:

PAIN: IT IS AN ANALGESIC

INFLAMMATION: IT IS AN ANTI-INFLAMMATORY

DEPRESSION AND ANXIETY

CANCER: IT HELPS TO REDUCE THE PROLIFERATION OF CANCER CELLS

ADDICTION: IT REDUCES ALCOHOL CRAVINGS

THE FUTURE OF MEDICINAL CANNABIS: CANNABINOIDS AND TERPENES

Currently, a great deal of research is being performed, studying the medicinal benefits of the various, most prevalent cannabinoids. However, studies in humans are still in their infancy.

As for terpenes, while far less research has been performed to date, terpenes seem to work in a synergistic manner with cannabinoids and other terpenes. Studies within the next few years and decades are sure to unlock more information.